Efficient Synthesis and Deprotection of Semicarbazones under Solvent-Free Conditions

Authors

Hamideh Hamzeali Islamic Azad University, East Tehran Branch, Tehran, I.R. IRAN

Javad Mokhtari Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114 Tehran, I.R. IRAN

Mohammad Gorban Dekamin Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114 Tehran, I.R. IRAN

Mohammad Reza Naimi-Jamal Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114 Tehran, I.R. IRAN

Shahrzad Javanshir Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114 Tehran, I.R. IRAN

Abstract:

Effective methodologies for efficient preparation of semicarbazones from aldehydes or ketones via milling and the subsequent regeneration of the parent carbonyls by gaseous nitrogen dioxide are described under solid-solid and gas-solid reaction conditions, respectively. These methods are fast, simple and environmentally benign which do not require the use of any auxiliaries such as catalysts or solid supports in their procedures.

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